Looking for additional suggestions to fix or troubleshoot the issue. Things that I have tried to resolve the issue. Granted I only was running Catalina for 2 days with the MacBook Pro 2019. Using the same USB hub and external devices I did not experience this issue with that configuration. This MacBook Air has replaced a late 2019 MacBook Pro that was running Mojave and then Catalina 10.15.4 for the last 2 days of use. I have attached a screen capture of what the USB device looks like normally when things are working correctly.
Disconnecting/reconnecting the USB Hub does not resolve the issue. The USB 2.0 HUB under System Information->Hardware->USB completely disappears until the MacBook is reported.
At random times during the day (2-3 times a day) my Logitech G602 mouse and external Apple Keyboard will stop responding completely and only a reboot will restore functionality. I have an external USB hub connected to one on my Thunderbolt 3/USB-C ports on my MacBook Air early 2020 model running Catalina 10.15.4.
